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Chinese parenteral phytomedicine reduces mortality from sepsis
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Chinese parenteral phytomedicine reduces mortality from sepsis
Sunday 1 October 2023, 01:00 AM
The licenced Chinese herbal medicine Xuebijing is prepared from a combination of plant extracts, including Carthamus tinctorius flowers (safflower) [Image: Pseudoanas via Wikimedia Commons]
Pharmacist and medical herbalist Phil Rasmussen reviews the results of a recent clinical trial that has put the potential role of phytotherapy for the treatment of sepsis into the spotlight
Sepsis is a life-threatening condition in which a dysregulated host response to infection leads to organ dysfunction. It has a complex pathophysiology
References
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- Namgung M, Ahn C, Park Y, et al. Mortality among adult patients with sepsis and septic shock in Korea: a systematic review and meta-analysis. Clin Exp Emerg Med 2023;10(2):157–71.
- Weng L, Xu Y, Yin P, et al. National incidence and mortality of hospitalized sepsis in China. Crit Care 2023;27(1):84.
- Fleischmann C, Scherag A, Adhikari NK, et al. Assessment of global incidence and mortality of hospital-treated sepsis. Current estimates and limitations. Am J Respir Crit Care Med 2016;193(3):259–72.
- Guarino M, Perna B, Cesaro AE, et al. 2023 update on sepsis and septic shock in adult patients: Management in the emergency department. J Clin Med 2023;12(9):3188.
- Varney J, Motawea KR, Kandil OA, et al. Prehospital administration of broad-spectrum antibiotics for sepsis patients: A systematic review and meta-analysis. Health Sci Rep 2022;5(3):e582.
- Taur Y, Xavier JB, Lipuma L, et al. Intestinal domination and the risk of bacteremia in patients undergoing allogeneic hematopoietic stem cell transplantation. Clin Infect Dis 2012;55(7):905–14.
- Im Y, Kang D, Ko RE, et al. Time-to-antibiotics and clinical outcomes in patients with sepsis and septic shock: a prospective nationwide multicenter cohort study. Crit Care 2022;26(1):19.
- Prescott HC, Dickson RP, Rogers MA, et al. Hospitalization type and subsequent severe sepsis. Am J Respir Crit Care Med 2015;192(5):581–88.
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- Cheng C, Yu X. Research progress in Chinese herbal medicines for treatment of sepsis: Pharmacological action, phytochemistry, and pharmacokinetics. Int J Mol Sci 2021;22(20):11078.
- Zhang L, Yang L, Shergis J, et al. Chinese herbal medicine for diabetic kidney disease: a systematic review and meta-analysis of randomised placebo-controlled trials. BMJ Open 2019;9(4):e025653.
- Wei M, Wang D, Kang D, et al. Overview of Cochrane reviews on Chinese herbal medicine for stroke. Integr Med Res 2020;9(1):5–9.
- Liu S, Yao C, Xie J, et al. Effect of an herbal-based injection on 28-day mortality in patients with sepsis: The EXIT-SEP randomized clinical trial. JAMA Intern Med 2023;183(7):647–55.
- Zhou W, Lai X, Wang X, et al. Network pharmacology to explore the anti-inflammatory mechanism of Xuebijing in the treatment of sepsis. Phytomedicine 2021;85:153543.
- Wang L, Liu Z, Dong Z, et al. Effects of Xuebijing injection on microcirculation in septic shock. J Surg Res 2016;202(1):147–54.
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